Ageing alters liver cell structure and function

Ageing is associated with gradual alteration of hepatic structure and liver functions including metabolism and detoxification. The associated high oxidative stress and inflammatory response may cause liver injury. Ageing also increases the risk of occurrence and development of age-related liver diseases.

Research 1: Ageing and liver disease

Liver is at a high risk for medication-induced damage

Liver is responsible for metabolizing medications, which makes it a prime target for medication-induced damage and liver injury. A broad range of medicines like antibiotics, anti-tuberculosis, antivirals, paracetamol, cardiac medications, anesthetics, and anticancer drugs can induce liver damage.

Research 1: Drug-induced liver injury

Excessive alcohol use may cause fatty liver disease

Chronic alcohol exposure increases oxidative stress, which damages the hepatocytes (liver cells). People with a deficiency of anti-oxidants such as glutathione and vitamin E are at a greater risk. Alcohol may also increase the deposition of fat in the liver, causing alcoholic fatty liver disease.

Research 1: Alcoholic liver disease

Obesity is a risk factor for non-alcoholic fatty liver disease (NAFLD)

NAFLD, the most common cause of chronic liver disease, is common in overweight or obese people. The disease occurs due to a build-up of fat in the liver. Old age and conditions such as type 2 diabetes, high blood pressure, and high cholesterol further increase the risk of developing NAFLD.

Research 1: Obesity and NAFLD

Research 2: NAFLD overview

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