Have you ever had redness, swelling, or burning in your palms or soles after some medications or treatment? It may be a hand-foot syndrome, which is usually a side effect of chemotherapy or targeted cancer therapy. It may involve mild discomfort all the way to painful peeling and blistering, which may impact your everyday life.
The condition can be disturbing, but it can also be managed through proper care and timely treatment. We are going to reveal the causes, symptoms, medical therapies, and natural remedies for hand-foot syndrome.
Understanding Hand Foot Syndrome
Hand-foot syndrome (HFS), also medically known as palmar-plantar erythrodysesthesia, is a skin disorder that occurs when the skin cells on the soles and palms are affected by chemotherapy or other medications.
In this syndrome, palms and soles are more affected because they contain a high number of small blood vessels and constant friction from daily activities like walking, gripping, or using tools. As a result, the medicine tend to accumulate more in these areas, leading to visible skin reactions. This condition is a common side effect of specific cancer treatments and varies in severity from person to person.
Causes of Hand Foot Syndrome
Hand-foot syndrome occurs when chemotherapy drugs leak out of the small blood vessels of the palms and soles. Chemotherapy is the most common cause of this health condition.
The most commonly used drugs that are linked with the hand and foot syndrome caused by chemotherapy are:
- Capecitabine
- 5-Fluorouracil (5-FU)
- Docetaxel
- Cytarabine
- Pegylated liposomal doxorubicin (PLD)
In cases where these medicines are circulating in the body, they are sometimes accumulate in the skin of the hands and feet. These parts are susceptible to damage due to the numerous sweat glands that can produce sweat, combined with friction and heat.
In addition to chemotherapy, targeted therapies, and certain immunotherapy drugs can also lead to hand and foot syndrome caused by inflammation or alterations in skin cell turnover.
They can also produce a condition similar to the hand-foot skin reaction (HFSR), in which thickened, calloused skin or blisters can develop in areas of pressure.
Symptoms of Hand Foot Syndrome
Symptom recognition is an important measure in avoiding complications. The feeling of hand-foot syndrome is different in one individual from another, though most people describe it as:
- Pain of a burning nature or itching.
- Sensation of tightness or straining of the skin.
- Sensation of pain during walking, holding, or even touching things.
- Increased sensitivity to temperature and pressure.
In extreme cases, the skin can blister or crack and result in sharp pains. These include symptoms that render even the most basic tasks, such as the ability to button a shirt, typing, or walk around the floor, uncomfortable.
Hand Foot Syndrome in Babies
HFS is very rare in babies because it is usually linked to chemotherapy drugs, which infants typically do not receive.
However, in extremely rare cases where a baby is on specific medications or treatments, mild symptoms can appear. In general, babies do not commonly develop Hand-Foot Syndrome unless they are undergoing special medical treatments.
Hand Foot Syndrome Treatment
Hand and foot syndrome treatment primarily aims to reduce symptoms, prevent infections, and safely continue cancer treatment.
Medical Hand-Foot Syndrome Treatments
- Dose Adjustment: Your oncologist can reduce or postpone the chemotherapy doses until the symptoms subside.
- Moisturising Creams: Unscented emollients, such as urea, lanolin, or aloe vera-based creams, are used to keep the skin moist and reduce friction.
- Topical Corticosteroids: This can be given to decrease inflammation and erythema.
- Pain Relievers: In cases of moderate or severe pain, painkillers may provide relief
How to Reduce the Risk of Hand-Foot Syndrome
Although medication is vital, natural remedies for hand-foot syndrome can be used in combination with therapeutic care to reduce the risk.
- Moisturise Frequently: Thick, unscented creams are applied multiple times per day, particularly after washing your hands or bathing
- Shun Heat and Friction: Keep off hot showers, saunas, and tight-fitting shoes. Watch out against actions that produce pressure on the palm or sole.
- Put on Soft Socks and Gloves: Cotton or gel-lined ones are recommended to minimise friction.
- Hydrate Well: The skin and body should be hydrated.
- Dietary Support: Consume foods that are rich in vitamins E and B6, antioxidants, and omega-3s to aid in skin healing.
- Aloe Vera Gel: Aloe is a natural anti-inflammatory soothing gel. Apply to surrounding areas.
- Coconut or Shea Butter: These are natural hydrators and barrier protectors.
These remedies will not cure the hand and foot syndrome, but they will help alleviate the symptoms and prevent deterioration.
Hand Foot Syndrome Supplements
Studies on the use of supplements as treatment for hand-foot syndrome are still being conducted. Some studies have explored:
- Vitamin B6 (Pyridoxine): It was found that pyridoxine (vitamin B6) may reduce the rate of hand-foot syndrome (HFS).
- Vitamin E: This is an antioxidant that could help prevent the skin cells from being damaged by chemotherapy.
- Omega-3 Fatty Acids: They may support skin repair and hydration.
Many supplements can interact with current medications or treatment, and therefore, you should never take them without consulting your doctor.
Conclusion
Living with hand-foot syndrome isn’t easy, but spotting symptoms early and protecting your skin through moisturising, avoiding heat, and reducing pressure can significantly reduce discomfort. When you understand the causes and warning signs, you’re better equipped to manage the condition and support healing.
If the pain, burning, or swelling becomes severe or starts to interfere with daily activities, seek medical advice immediately. Your doctor can modify your treatment plan and suggest therapies that offer safe and effective relief during your recovery.
Frequently Asked Questions Related to Hand and Foot Syndrome
What is the cause of the hand-foot syndrome?
Capecitabine, 5-fluorouracil, and pegylated liposomal doxorubicin are the chemotherapy drugs that primarily cause hand-foot syndrome.
What is the treatment of hand-foot syndrome?
Various treatments for the syndrome include varying the dose of chemotherapy, using topical steroids and moisturisers, cold compresses and remaining hydrated and taking adequate rest.
What is the duration it takes you to get rid of the hand and foot syndrome?
In most cases, it takes 2-5 weeks following chemotherapy withdrawal before symptoms fade away.
What are some of the good supplements to use and hand hand-foot syndrome?
Vitamin B6, vitamin E, and omega-3 fatty acids are supplements that could help heal the skin. Never start taking any supplement without the advice of a physician.
What does hand-foot syndrome feel like?
Patients usually complain of the hand and foot syndrome, which is a burning, tingling, or painful sensation in the hands and feet. The skin will turn erythema, tight, sensitive, and will crack or peel without treatment.
